Fatty acyl-carnitine + CoA 2. Fatty acyl-carnitine enters matrix 3. CAT-2 (embedded in inner membrane): Fatty acyl-carnitine --> Carnitine + Fatty acyl CoA BETA-OXIDATION • Breaks down fatty acids in 2C increments (acetyl CoA) + shorter chain fatty acid • Req. four reactions per 2C increment • All reactions occur at beta-carbon (beta-oxidation) Each 2C increment i. Oxidation • Acyl CoA dehydrogenases (ACAD): family of chain-length specific enzymes • Releases FADH2 (~ 2 ATP via oxidative phosphorylation) i..." />
Fatty acyl-carnitine + CoA 2. Fatty acyl-carnitine enters matrix 3. CAT-2 (embedded in inner membrane): Fatty acyl-carnitine --> Carnitine + Fatty acyl CoA BETA-OXIDATION • Breaks down fatty acids in 2C increments (acetyl CoA) + shorter chain fatty acid • Req. four reactions per 2C increment • All reactions occur at beta-carbon (beta-oxidation) Each 2C increment i. Oxidation • Acyl CoA dehydrogenases (ACAD): family of chain-length specific enzymes • Releases FADH2 (~ 2 ATP via oxidative phosphorylation) i..."/>
Fatty acyl-carnitine + CoA 2. Fatty acyl-carnitine enters matrix 3. CAT-2 (embedded in inner membrane): Fatty acyl-carnitine --> Carnitine + Fatty acyl CoA BETA-OXIDATION • Breaks down fatty acids in 2C increments (acetyl CoA) + shorter chain fatty acid • Req. four reactions per 2C increment • All reactions occur at beta-carbon (beta-oxidation) Each 2C increment i. Oxidation • Acyl CoA dehydrogenases (ACAD): family of chain-length specific enzymes • Releases FADH2 (~ 2 ATP via oxidative phosphorylation) i...">
Fatty acyl-carnitine + CoA 2. Fatty acyl-carnitine enters matrix 3. CAT-2 (embedded in inner membrane): Fatty acyl-carnitine --> Carnitine + Fatty acyl CoA BETA-OXIDATION • Breaks down fatty acids in 2C increments (acetyl CoA) + shorter chain fatty acid • Req. four reactions per 2C increment • All reactions occur at beta-carbon (beta-oxidation) Each 2C increment i. Oxidation • Acyl CoA dehydrogenases (ACAD): family of chain-length specific enzymes • Releases FADH2 (~ 2 ATP via oxidative phosphorylation) i...">